Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
NCT04269902
This study is recruiting at 290 US sites in 35 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Chronic Lymphocytic Leukemia
- Small Lymphocytic Lymphoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 1
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro · Jonesboro, AR
California · 31
- Kaiser Permanente-Anaheim · Anaheim, CA
- Kaiser Permanente-Baldwin Park · Baldwin Park, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Marshall Cancer Center · Cameron Park, CA
- Enloe Medical Center · Chico, CA
- UC Irvine Health Cancer Center-Newport · Costa Mesa, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Kaiser Permanente-Fontana · Fontana, CA
- Kaiser Permanente South Bay · Harbor City, CA
- City of Hope Seacliff · Huntington Beach, CA
- City of Hope at Irvine Lennar · Irvine, CA
- Kaiser Permanente-Irvine · Irvine, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UCI Health Laguna Hills · Laguna Hills, CA
- City of Hope Antelope Valley · Lancaster, CA
- City of Hope at Long Beach Elm · Long Beach, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente West Los Angeles · Los Angeles, CA
- Fremont - Rideout Cancer Center · Marysville, CA
- City of Hope Newport Beach · Newport Beach, CA
- Kaiser Permanente-Ontario · Ontario, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Kaiser Permanente-Riverside · Riverside, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Kaiser Permanente-San Diego Zion · San Diego, CA
- Kaiser Permanente-San Marcos · San Marcos, CA
- City of Hope South Pasadena · South Pasadena, CA
- City of Hope South Bay · Torrance, CA
- City of Hope Upland · Upland, CA
- Kaiser Permanente-Woodland Hills · Woodland Hills, CA
Colorado · 1
- Grand Valley Oncology · Grand Junction, CO
Delaware · 4
- Beebe South Coastal Health Campus · Millville, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
District of Columbia · 1
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 1
- Holy Cross Hospital · Fort Lauderdale, FL
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 31
- Rush-Copley Medical Center · Aurora, IL
- Northwestern University · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Ingalls Memorial Hospital · Harvey, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Edward Hospital/Cancer Center · Naperville, IL
- UC Comprehensive Cancer Center at Silver Cross · New Lenox, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- University of Chicago Medicine-Orland Park · Orland Park, IL
- Edward Hospital/Cancer Center?Plainfield · Plainfield, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Carle Cancer Center · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Indiana · 2
- UChicago Medicine Northwest Indiana · Crown Point, IN
- Indiana University/Melvin and Bren Simon Cancer Center · Indianapolis, IN
Iowa · 13
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Physicians' Clinic of Iowa PC · Cedar Rapids, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
Kansas · 8
- HaysMed · Hays, KS
- University of Kansas Cancer Center · Kansas City, KS
- Lawrence Memorial Hospital · Lawrence, KS
- The University of Kansas Cancer Center - Olathe · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- Salina Regional Health Center · Salina, KS
- University of Kansas Health System Saint Francis Campus · Topeka, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Maine · 7
- Harold Alfond Center for Cancer Care · Augusta, ME
- MaineHealth Cancer Care and IV Therapy - Brunswick · Brunswick, ME
- Mid Coast Hospital · Brunswick, ME
- MaineHealth LincolnHealth Hospital · Damariscotta, ME
- MaineHealth Maine Medical Center - Portland · Portland, ME
- MaineHealth Maine Medical Center- Scarborough · Scarborough, ME
- MaineHealth Cancer Care and IV Therapy - South Portland · South Portland, ME
Maryland · 2
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Walter Reed National Military Medical Center · Bethesda, MD
Massachusetts · 3
- Dana-Farber Cancer Institute · Boston, MA
- Tufts Medical Center · Boston, MA
- Tufts Medical Center Cancer Center Stoneham · Stoneham, MA
Michigan · 37
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Henry Ford Hospital · Detroit, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Van Elslander · Grosse Pointe Woods, MI
- Allegiance Health · Jackson, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Henry Ford Health Providence Novi Hospital · Novi, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Newland Medical Associates-Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health Reed City Hospital · Reed City, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Munson Medical Center · Traverse City, MI
- Henry Ford Health Warren Hospital · Warren, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.