A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
NCT04251052
This study is recruiting at 479 US sites in 46 states, according to its ClinicalTrials.gov record last updated .
Summary
This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Ovarian Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 35 to 50 years
- Sex
- Female
- Healthy volunteers
- Not accepted
- Sponsor
- NRG Oncology
- Last updated on ClinicalTrials.gov
- August 7, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Alaska · 6
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
Arizona · 2
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
Arkansas · 1
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 60
- Kaiser Permanente-Deer Valley Medical Center · Antioch, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Keck Medicine of USC Buena Park · Buena Park, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Kaiser Permanente Dublin · Dublin, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Kaiser Permanente Fresno Orchard Plaza · Fresno, CA
- Kaiser Permanente-Fresno · Fresno, CA
- City of Hope Seacliff · Huntington Beach, CA
- Keck Medicine of USC Huntington Beach · Huntington Beach, CA
- City of Hope at Irvine Lennar · Irvine, CA
- Kaiser Permanente-Irvine · Irvine, CA
- City of Hope Antelope Valley · Lancaster, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Keck Medicine of USC Koreatown · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- UCLA / Jonsson Comprehensive Cancer Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Kaiser Permanente- Modesto MOB II · Modesto, CA
- Kaiser Permanente-Modesto · Modesto, CA
- Providence Queen of The Valley · Napa, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Huntington Memorial Hospital · Pasadena, CA
- Keck Medical Center of USC Pasadena · Pasadena, CA
- Kaiser Permanente- Marshall Medical Offices · Redwood City, CA
- Kaiser Permanente-Redwood City · Redwood City, CA
- Kaiser Permanente-Richmond · Richmond, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Kaiser Permanente-Roseville · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- UCSF Medical Center-Mission Bay · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
- City of Hope South Pasadena · South Pasadena, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Kaiser Permanente-Stockton · Stockton, CA
- City of Hope South Bay · Torrance, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- City of Hope Upland · Upland, CA
- Kaiser Permanente Medical Center-Vacaville · Vacaville, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 8
- UCHealth University of Colorado Hospital · Aurora, CO
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 8
- Danbury Hospital · Danbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Hartford Hospital · Hartford, CT
- The Hospital of Central Connecticut · New Britain, CT
- Smilow Cancer Center/Yale-New Haven Hospital · New Haven, CT
- Yale University · New Haven, CT
- Norwalk Hospital · Norwalk, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 4
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
Florida · 28
- UM Sylvester Comprehensive Cancer Center at Aventura · Aventura, FL
- Florida Cancer Specialists - Bradenton Cancer Center · Bradenton, FL
- Morton Plant Hospital · Clearwater, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- Florida Cancer Specialists-Englewood · Englewood, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Jackson Memorial Hospital-Holtz Children's Hospital · Miami, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Sarasota Memorial Hospital-Venice · Nokomis, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- First Physicians Group - Gastroenterology Obesity Medicine · Sarasota, FL
- First Physicians Group - Silverstein Institute at Floyd Street · Sarasota, FL
- First Physicians Group - Urology Robotic and Minimally Invasive Surgery · Sarasota, FL
- Florida Cancer Specialists - Sarasota · Sarasota, FL
- Florida Cancer Specialists - Sarasota Downtown · Sarasota, FL
- FPG - Surgical Oncology Clinics Gastrointestinal Oncology Surgery · Sarasota, FL
- FPG - Surgical Oncology Clinics Gynecologic Oncology Surgery · Sarasota, FL
- Intercoastal Medical Group - Cattleridge II · Sarasota, FL
- Sarasota Memorial Health Care Center at University Parkway · Sarasota, FL
- Sarasota Memorial Hospital · Sarasota, FL
- Saint Anthony's Hospital Cancer Care Center · St. Petersburg, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
- Florida Cancer Specialists - Venice Island · Venice, FL
- Florida Cancer Specialists - Venice Pinebrook · Venice, FL
Georgia · 7
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Northside Hospital · Atlanta, GA
- Emory Decatur Hospital · Decatur, GA
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler · Savannah, GA
Hawaii · 1
- Kaiser Permanente Moanalua Medical Center · Honolulu, HI
Idaho · 5
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 19
- Advocate Outpatient Center - Aurora · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Carle BroMenn Outpatient Center · Bloomington, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.