Trial-Ready Cohort-Down Syndrome (TRC-DS)
NCT04165109
This study is recruiting at 14 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS) study. Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic and biomarker testing, as well as imaging and biospecimen collection.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Down Syndrome
- Alzheimer Disease
- Dementia
Eligibility basics and study details
- Study type
- Observational
- Phase
- Not applicable
- Ages
- 25 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- University of Southern California
- Last updated on ClinicalTrials.gov
- May 18, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Barrow Neurological Institute · Phoenix, AZ
California · 1
- University of California, Irvine School of Medicine, Co-Enrolling through ABC-DS Only · Orange, CA
Colorado · 1
- Linda Crnic Institute for Down Syndrome, University of Colorado · Aurora, CO
Indiana · 1
- Indiana University · Indianapolis, IN
Kansas · 1
- University of Kansas Medical Center · Kansas City, KS
Kentucky · 1
- University of Kentucky, Co-Enrolling through ABC-DS Only · Lexington, KY
Massachusetts · 1
- Massachusetts General Hospital, Co-Enrolling through ABC-DS Only · Boston, MA
Missouri · 1
- Washington University, St. Louis · St Louis, MO
New York · 1
- New York State Institute for Basic Research in Developmental Disabilities (SIBRDD), Co-Enrolling through ABC-DS Only · Staten Island, NY
Ohio · 1
- Case Western Reserve University · Beachwood, OH
Pennsylvania · 1
- University of Pittsburgh, Co-Enrolling through ABC-DS Only · Pittsburgh, PA
Tennessee · 1
- Vanderbilt University Medical Center Center for Cognitive Medicine · Nashville, TN
Texas · 1
- University of Texas Health San Antonio, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases · San Antonio, TX
Wisconsin · 1
- University of Wisconsin - Madison, Waisman Center, Co-Enrolling through ABC-DS Only · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.