Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
NCT04031677
This study is recruiting at 103 US sites in 31 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Retroperitoneal Sarcoma
- Liposarcoma
- Leiomyosarcoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
- Last updated on ClinicalTrials.gov
- October 7, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Mayo Clinic Hospital in Arizona · Phoenix, AZ
California · 4
- City of Hope Comprehensive Cancer Center · Duarte, CA
- UCI Health-Chao Family Comp CC and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- UC Irvine Health/Chao Family Comprehensive Ca Ctr · Orange, CA
Colorado · 1
- UCHealth University of Colorado Hospital · Aurora, CO
Connecticut · 12
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guiford · Guilford, CT
- Smilow Cancer Hospital Care Ctr at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Florida · 5
- Univ of Florida Health Science Ctr - Gainesville · Gainesville, FL
- Mayo Clinic in Florida · Jacksonville, FL
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
Georgia · 1
- Emory University Hospital Midtown · Atlanta, GA
Illinois · 3
- Rush University Medical Center · Chicago, IL
- University of Illinois at Chicago MBCCOP · Chicago, IL
- Midwestern Regional Medical Center · Zion, IL
Kansas · 3
- University of Kansas Cancer Center · Kansas City, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Westwood Cancer Ctr · Westwood, KS
Kentucky · 2
- James Graham Brown Ca Ctr at Univ of Louisville · Louisville, KY
- UofL Health Medical Center Northeast · Louisville, KY
Louisiana · 3
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of The Lake Hospital · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
Massachusetts · 1
- Dana-Farber/Harvard Cancer Center · Boston, MA
Michigan · 1
- University of Michigan Comprehensive Cancer Center · Ann Arbor, MI
Minnesota · 2
- Sanford Joe Lueken Cancer Center · Bemidji, MN
- Mayo Clinic · Rochester, MN
Missouri · 3
- Siteman Cancer Center-West County · Creve Coeur, MO
- Siteman Cancer Center-South Country · St Louis, MO
- Washington University School of Medicine - Siteman Cancer Center · St Louis, MO
Nebraska · 3
- Nebraska Medicine-Bellevue · Bellevue, NE
- Nebraska Medicine-Bellevue · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
Nevada · 1
- Renown Regional Medical Center · Reno, NV
New Jersey · 5
- Cooper Hospital University Medical Center · Camden, NJ
- HMH-Hackensack University Medical Center · Hackensack, NJ
- Jersey Shore University Medical Center · Neptune City, NJ
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
- John Theurer Cancer Center at From Road · Paramus, NJ
New York · 9
- Roswell Park Cancer Institute · Buffalo, NY
- Northwell Health/Center for Advanced Medicine · Lake Success, NY
- North Shore University Hospital · Manhasset, NY
- NYU Langone Hospital - Long Island · Mineola, NY
- Long Island Jewish Medical Center · New Hyde Park, NY
- Laura and Issac Perlmutter Ca Ctr at NYU Langone · New York, NY
- University of Rochester · Rochester, NY
- Montefiore Medical Center - Moses Campus · The Bronx, NY
- Montefiore Medical Center-Einstein Campus · The Bronx, NY
North Carolina · 2
- Carolinas Medical Center/Levine Cancer Institute · Charlotte, NC
- Duke University Medical Center · Durham, NC
Ohio · 1
- Ohio State University Comprehensive Cancer Center · Columbus, OH
Oklahoma · 1
- University of Oklahoma Health Sciences Center · Oklahoma City, OK
Oregon · 1
- Oregon Health and Science University · Portland, OR
Pennsylvania · 12
- Saint Vincent Hospital · Erie, PA
- Jefferson Hospital · Jefferson Hills, PA
- Forbes Hospital · Monroeville, PA
- Allegheny Valley Hospital · Natrona Heights, PA
- Fox Chase Cancer Center · Philadelphia, PA
- Pennsylvania Hospital · Philadelphia, PA
- Thomas Jefferson University Hospital · Philadelphia, PA
- University of Pennsylvania/Abramson Cancer Center · Philadelphia, PA
- Allegheny General Hospital · Pittsburgh, PA
- UPMC Hillman Cancer Center · Pittsburgh, PA
- West Penn Hospital · Pittsburgh, PA
- Wexford Health and Wellness Pavilion · Wexford, PA
Rhode Island · 2
- Rhode Island Hospital · Providence, RI
- Smilow Cancer Hospital Care Center - Westerly · Westerly, RI
Tennessee · 2
- University of Tennessee - Knoxville · Knoxville, TN
- Vanderbilt University/Ingram Cancer Center · Nashville, TN
Texas · 2
- UT Southwestern/Simmons Cancer Center-Dallas · Dallas, TX
- M D Anderson Cancer Center · Houston, TX
Utah · 1
- Huntsman Cancer Institute/University of Utah · Salt Lake City, UT
Vermont · 2
- University of Vermont Medical Center · Burlington, VT
- Vermont Regional Cancer Center · Burlington, VT
Virginia · 4
- VCU Massey Cancer Center at Hanover Medical Park · Mechanicsville, VA
- VCU Massey Cancer Center at Stony Point · Richmond, VA
- Virginia Commonwealth Univ/Massey Cancer Center · Richmond, VA
- Carilion Roanoke Memorial Hospital · Roanoke, VA
Washington · 2
- Fred Hutchinson Cancer Center · Seattle, WA
- University of Washington Medical Center - Montlake · Seattle, WA
Wisconsin · 11
- Marshfield Medical Center-EC Cancer Center · Eau Claire, WI
- Marshfield Medical Center · Marshfield, WI
- Froedtert Menomonee Falls Hospital · Menomonee Falls, WI
- Medical College of Wisconsin · Milwaukee, WI
- Marshfield Medical Center · Minocqua, WI
- Froedtert and MCW Moorland Reserve Health Center · New Berlin, WI
- Drexel Town Square Health Center · Oak Creek, WI
- Marshfield Medical Center · Rice Lake, WI
- Marshfield Med Ctr-River Region at Stevens Point · Stevens Point, WI
- Froedtert West Bend Hospital/Kraemer Cancer Center · West Bend, WI
- Marshfield Medical Center · Weston, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.