Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
NCT03937635
This study is recruiting at 482 US sites in 44 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as daratumumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Smoldering Plasma Cell Myeloma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- ECOG-ACRIN Cancer Research Group
- Last updated on ClinicalTrials.gov
- August 19, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Alaska · 6
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
Arizona · 3
- CTCA at Western Regional Medical Center · Goodyear, AZ
- Kingman Regional Medical Center · Kingman, AZ
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 1
- Mercy Hospital Fort Smith · Fort Smith, AR
California · 14
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- PCR Oncology · Arroyo Grande, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Contra Costa Regional Medical Center · Martinez, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Saint Joseph's Medical Center · Stockton, CA
- BASS Medical Group - Lennon · Walnut Creek, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 14
- Rocky Mountain Cancer Centers-Aurora · Aurora, CO
- Boulder Community Foothills Hospital · Boulder, CO
- Rocky Mountain Cancer Centers-Boulder · Boulder, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- Presbyterian - Saint Lukes Medical Center - Health One · Denver, CO
- The Melanoma and Skin Cancer Institute · Englewood, CO
- CommonSpirit Saint Anthony Hospital Cancer Center · Lakewood, CO
- Rocky Mountain Cancer Centers-Littleton · Littleton, CO
- Longmont United Hospital · Longmont, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- Rocky Mountain Cancer Centers-Thornton · Thornton, CO
- Saint Anthony North Hospital · Westminster, CO
Connecticut · 15
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Smilow Cancer Center/Yale-New Haven Hospital · New Haven, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital-Orange Care Center · Orange, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Florida · 2
- Holy Cross Hospital · Fort Lauderdale, FL
- Cleveland Clinic-Weston · Weston, FL
Georgia · 8
- Phoebe Putney Memorial Hospital · Albany, GA
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- John B Amos Cancer Center · Columbus, GA
- Emory Johns Creek Hospital · Johns Creek, GA
- Lewis Hall Singletary Oncology Center · Thomasville, GA
- South Georgia Medical Center/Pearlman Cancer Center · Valdosta, GA
Idaho · 11
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Idaho Urologic Institute-Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 51
- OSF Saint Anthony's Health Center · Alton, IL
- Advocate Outpatient Center - Aurora · Aurora, IL
- Rush-Copley Medical Center · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Swedish Covenant Hospital · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 1
- Reid Health · Richmond, IN
Iowa · 16
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- University of Iowa Healthcare Cancer Services Quad Cities · Bettendorf, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Greater Regional Medical Center · Creston, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Lutheran Hospital · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
- Methodist West Hospital · West Des Moines, IA
Kansas · 3
- Central Care Cancer Center - Garden City · Garden City, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
- Cotton O'Neil Cancer Center / Stormont Vail Health · Topeka, KS
Kentucky · 4
- CommonSpirit Saint Joseph Hospital - Lexington · Lexington, KY
- CommonSpirit Saint Joseph Medical Center - East Lexington · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.