Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change
NCT03191149
This study is recruiting at 212 US sites in 22 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial studies how well osimertinib works in treating patients with non-small cell lung cancer with EGFR exon 20 insertion mutation that is stage IIIB-IV or has come back after a period of improvement (recurrent). Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Lung Non-Small Cell Carcinoma
- Recurrent Lung Non-Small Cell Carcinoma
- Stage IIIB Lung Non-Small Cell Cancer AJCC v7
- Stage IV Lung Non-Small Cell Cancer AJCC v7
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 1
- Fairbanks Memorial Hospital · Fairbanks, AK
Arkansas · 2
- Mercy Hospital Fort Smith · Fort Smith, AR
- CARTI Cancer Center · Little Rock, AR
District of Columbia · 1
- MedStar Georgetown University Hospital · Washington D.C., DC
Florida · 1
- Holy Cross Hospital · Fort Lauderdale, FL
Georgia · 3
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
Idaho · 7
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Idaho Urologic Institute-Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 36
- OSF Saint Anthony's Health Center · Alton, IL
- Rush-Copley Medical Center · Aurora, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Illinois CancerCare - Washington · Washington, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Kansas · 3
- Central Care Cancer Center - Garden City · Garden City, KS
- Central Care Cancer Center - Great Bend · Great Bend, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
Massachusetts · 1
- Massachusetts General Hospital Cancer Center · Boston, MA
Michigan · 50
- MyMichigan Medical Center Gratiot · Alma, MI
- MyMichigan Medical Center Alpena · Alpena, MI
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Trinity Health IHA Medical Group - Primary Care - Clarkston · Clarkston, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Henry Ford Hospital · Detroit, MI
- Cancer Hematology Centers - Flint · Flint, MI
- Genesee Hematology Oncology PC · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- MyMichigan Medical Center Gladwin · Gladwin, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital · Grand Rapids, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Breast · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Van Elslander · Grosse Pointe Woods, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Henry Ford Saint John Hospital - Macomb Medical · Macomb, MI
- Henry Ford Warren Hospital - Breast Macomb · Macomb, MI
- MyMichigan Medical Center Midland · Midland, MI
- MyMichigan Medical Center Mount Pleasant · Mount Pleasant, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Henry Ford Health Providence Novi Hospital · Novi, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Newland Medical Associates-Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health Reed City Hospital · Reed City, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Henry Ford Health Providence Southfield Hospital · Southfield, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Munson Medical Center · Traverse City, MI
- Henry Ford Health Warren Hospital · Warren, MI
- Henry Ford Madison Heights Hospital - Breast · Warren, MI
- Henry Ford Warren Hospital - GLCMS · Warren, MI
- University of Michigan Health - West · Wyoming, MI
- Huron Gastroenterology PC · Ypsilanti, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 28
- Minnesota Oncology - Burnsville · Burnsville, MN
- Cambridge Medical Center · Cambridge, MN
- Minnesota Oncology Hematology PA-Chaska · Chaska, MN
- Mercy Hospital · Coon Rapids, MN
- Minnesota Oncology - Coon Rapids · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Minnesota Oncology - Edina · Edina, MN
- Fairview Clinics and Surgery Center Maple Grove · Maple Grove, MN
- HealthPartners Cancer Care - Park Nicollet Maple Grove · Maple Grove, MN
- Minnesota Oncology - Maple Grove · Maple Grove, MN
- Minnesota Oncology Hematology PA-Maplewood · Maplewood, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Health Partners Inc · Minneapolis, MN
- Monticello Cancer Center · Monticello, MN
- New Ulm Medical Center · New Ulm, MN
- Fairview Northland Medical Center · Princeton, MN
- North Memorial Medical Health Center · Robbinsdale, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Lakeview Hospital · Stillwater, MN
- Ridgeview Medical Center · Waconia, MN
- Rice Memorial Hospital · Willmar, MN
- Fairview Cancer Center - Woodbury · Woodbury, MN
- Minnesota Oncology Hematology PA-Woodbury · Woodbury, MN
- Fairview Lakes Medical Center · Wyoming, MN
Missouri · 17
- Mercy Oncology and Hematology - Clayton-Clarkson · Ballwin, MO
- Central Care Cancer Center - Bolivar · Bolivar, MO
- Cox Cancer Center Branson · Branson, MO
- Mercy Cancer Center - Cape Girardeau · Cape Girardeau, MO
- Saint Francis Medical Center · Cape Girardeau, MO
- Parkland Health Center - Farmington · Farmington, MO
- Freeman Health System · Joplin, MO
- Mercy Hospital Joplin · Joplin, MO
- Lake Regional Hospital · Osage Beach, MO
- Mercy Clinic-Rolla-Cancer and Hematology · Rolla, MO
- Phelps Health Delbert Day Cancer Institute · Rolla, MO
- Heartland Regional Medical Center · Saint Joseph, MO
- Sainte Genevieve County Memorial Hospital · Sainte Genevieve, MO
- CoxHealth South Hospital · Springfield, MO
- Mercy Hospital Springfield · Springfield, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Mercy Hospital South · St Louis, MO
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.