Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
NCT03067181
This study is recruiting at 382 US sites in 49 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Childhood Extracranial Germ Cell Tumor
- Extragonadal Embryonal Carcinoma
- Germ Cell Tumor
- Malignant Germ Cell Tumor
- Malignant Ovarian Teratoma
- Stage I Ovarian Choriocarcinoma
- Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage I Testicular Choriocarcinoma AJCC v6 and v7
- Stage I Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage I Testicular Seminoma AJCC v6 and v7
- Stage I Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage II Ovarian Choriocarcinoma
- Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage II Testicular Choriocarcinoma AJCC v6 and v7
- Stage II Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage II Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage III Ovarian Choriocarcinoma
- Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage III Testicular Choriocarcinoma AJCC v6 and v7
- Stage III Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage III Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage IV Ovarian Choriocarcinoma
- Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7
- Testicular Mixed Choriocarcinoma and Embryonal Carcinoma
- Testicular Mixed Choriocarcinoma and Teratoma
- Testicular Mixed Choriocarcinoma and Yolk Sac Tumor
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- Any age
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Children's Oncology Group
- Last updated on ClinicalTrials.gov
- August 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Children's Hospital of Alabama · Birmingham, AL
Alaska · 6
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
Arizona · 3
- Kingman Regional Medical Center · Kingman, AZ
- Banner Children's at Desert · Mesa, AZ
- Phoenix Childrens Hospital · Phoenix, AZ
Arkansas · 2
- Arkansas Children's Hospital · Little Rock, AR
- CARTI Cancer Center · Little Rock, AR
California · 26
- Kaiser Permanente-Anaheim · Anaheim, CA
- PCR Oncology · Arroyo Grande, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Kaiser Permanente Downey Medical Center · Downey, CA
- Kaiser Permanente-Fontana · Fontana, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Loma Linda University Medical Center · Loma Linda, CA
- Miller Children's and Women's Hospital Long Beach · Long Beach, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Children's Hospital Los Angeles · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Mattel Children's Hospital UCLA · Los Angeles, CA
- Valley Children's Hospital · Madera, CA
- Providence Queen of The Valley · Napa, CA
- Kaiser Permanente-Oakland · Oakland, CA
- UCSF Benioff Children's Hospital Oakland · Oakland, CA
- Children's Hospital of Orange County · Orange, CA
- Lucile Packard Children's Hospital Stanford University · Palo Alto, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Kaiser Permanente-San Diego Mission · San Diego, CA
- Naval Medical Center -San Diego · San Diego, CA
- Rady Children's Hospital - San Diego · San Diego, CA
- UCSF Medical Center-Mission Bay · San Francisco, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
Colorado · 2
- Children's Hospital Colorado · Aurora, CO
- Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center · Denver, CO
Connecticut · 2
- Connecticut Children's Medical Center · Hartford, CT
- Yale University · New Haven, CT
Delaware · 1
- Alfred I duPont Hospital for Children · Wilmington, DE
District of Columbia · 1
- Children's National Medical Center · Washington D.C., DC
Florida · 16
- Broward Health Medical Center · Fort Lauderdale, FL
- Golisano Children's Hospital of Southwest Florida · Fort Myers, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Nemours Children's Clinic-Jacksonville · Jacksonville, FL
- Miami Cancer Institute · Miami, FL
- Nicklaus Children's Hospital · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- AdventHealth Orlando · Orlando, FL
- Arnold Palmer Hospital for Children · Orlando, FL
- Nemours Children's Hospital · Orlando, FL
- Nemours Children's Clinic - Pensacola · Pensacola, FL
- Johns Hopkins All Children's Hospital · St. Petersburg, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
- Tampa General Hospital · Tampa, FL
- Saint Mary's Medical Center · West Palm Beach, FL
Georgia · 4
- Children's Healthcare of Atlanta - Arthur M Blank Hospital · Atlanta, GA
- Augusta University Medical Center · Augusta, GA
- Atrium Health Navicent · Macon, GA
- Memorial Health University Medical Center · Savannah, GA
Hawaii · 2
- Kapiolani Medical Center for Women and Children · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
Idaho · 5
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 40
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Lurie Children's Hospital-Chicago · Chicago, IL
- University of Chicago Comprehensive Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- NorthShore University HealthSystem-Evanston Hospital · Evanston, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- NorthShore University HealthSystem-Glenbrook Hospital · Glenview, IL
- NorthShore University HealthSystem-Highland Park Hospital · Highland Park, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Loyola University Medical Center · Maywood, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Advocate Children's Hospital-Oak Lawn · Oak Lawn, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Children's Hospital-Park Ridge · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- OSF Saint Francis Radiation Oncology at Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- OSF Children's Hospital of Illinois · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Saint John's Hospital · Springfield, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 2
- Ascension Saint Vincent Indianapolis Hospital · Indianapolis, IN
- Riley Hospital for Children · Indianapolis, IN
Iowa · 13
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Greater Regional Medical Center · Creston, IA
- Blank Children's Hospital · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
- The Iowa Clinic PC · West Des Moines, IA
Kansas · 1
- Wesley Medical Center · Wichita, KS
Kentucky · 2
- University of Kentucky/Markey Cancer Center · Lexington, KY
- Norton Children's Hospital · Louisville, KY
Louisiana · 3
- Children's Hospital New Orleans · New Orleans, LA
- Ochsner Medical Center Jefferson · New Orleans, LA
- University Medical Center New Orleans · New Orleans, LA
Maine · 4
- Eastern Maine Medical Center · Bangor, ME
- MaineHealth Maine Medical Center - Portland · Portland, ME
- Maine Children's Cancer Program · Scarborough, ME
- MaineHealth Maine Medical Center- Scarborough · Scarborough, ME
Maryland · 4
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Sinai Hospital of Baltimore · Baltimore, MD
- University of Maryland/Greenebaum Cancer Center · Baltimore, MD
- Walter Reed National Military Medical Center · Bethesda, MD
Massachusetts · 5
- Dana-Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital Cancer Center · Boston, MA
- Tufts Medical Center · Boston, MA
- Baystate Medical Center · Springfield, MA
- UMass Memorial Medical Center - University Campus · Worcester, MA
Michigan · 5
- C S Mott Children's Hospital · Ann Arbor, MI
- University of Michigan Rogel Cancer Center · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Children's Hospital of Michigan · Detroit, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.