Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
NCT02523014
This study is recruiting at 410 US sites in 39 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting worse (progressive). Vismodegib, FAK inhibitor GSK2256098, capivasertib, and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Intracranial Meningioma
- Recurrent Meningioma
- NF2 Gene Mutation
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Alliance for Clinical Trials in Oncology
- Last updated on ClinicalTrials.gov
- October 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 1
- Fairbanks Memorial Hospital · Fairbanks, AK
Arizona · 2
- Kingman Regional Medical Center · Kingman, AZ
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 2
- Mercy Hospital Fort Smith · Fort Smith, AR
- CARTI Cancer Center · Little Rock, AR
California · 17
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- PCR Oncology · Arroyo Grande, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Mercy Cancer Center · Merced, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Saint Joseph's Medical Center · Stockton, CA
- Torrance Memorial Medical Center · Torrance, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 10
- UCHealth University of Colorado Hospital · Aurora, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- CommonSpirit Cancer Center Mercy · Durango, CO
- Mercy Medical Center · Durango, CO
- CommonSpirit Saint Anthony Hospital Cancer Center · Lakewood, CO
- Longmont United Hospital · Longmont, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- Saint Anthony North Hospital · Westminster, CO
Connecticut · 3
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
Florida · 9
- Boca Raton Regional Hospital · Boca Raton, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- Holy Cross Hospital · Fort Lauderdale, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Mayo Clinic in Florida · Jacksonville, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Memorial Hospital West · Pembroke Pines, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- Tampa General Hospital · Tampa, FL
Georgia · 4
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Piedmont Hospital · Atlanta, GA
Idaho · 6
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Idaho Urologic Institute-Meridian · Meridian, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 57
- OSF Saint Anthony's Health Center · Alton, IL
- Rush-Copley Medical Center · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Advocate Outpatient Center - Oak Lawn · Oak Lawn, IL
- Rush MD Anderson Cancer Center at Rush Oak Park · Oak Park, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate High Tech Medical Park · Palos Heights, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- OSF Saint Francis Radiation Oncology at Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
- Rush-Copley Healthcare Center · Yorkville, IL
Iowa · 9
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Des Moines Clinic · Des Moines, IA
- UI Health Care Mission Cancer and Blood - Laurel Clinic · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
- UI Health Care Mission Cancer and Blood - Waukee Clinic · Waukee, IA
- Mercy Medical Center-West Lakes · West Des Moines, IA
Kansas · 2
- Central Care Cancer Center - Great Bend · Great Bend, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
Kentucky · 8
- CommonSpirit Saint Joseph Hospital - Bardstown · Bardstown, KY
- Commonwealth Cancer Center-Corbin · Corbin, KY
- CommonSpirit Saint Joseph Hospital - Lexington · Lexington, KY
- CommonSpirit Saint Joseph Medical Center - East Lexington · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- CommonSpirit Saint Joseph Hospital London · London, KY
- Norton Brownsboro Hospital and Medical Campus · Louisville, KY
- CommonSpirit Saint Joseph Hospital Mount Sterling · Mount Sterling, KY
Maryland · 1
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
Massachusetts · 2
- Dana-Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital Cancer Center · Boston, MA
Michigan · 17
- MyMichigan Medical Center Gratiot · Alma, MI
- MyMichigan Medical Center Alpena · Alpena, MI
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Trinity Health IHA Medical Group - Primary Care - Clarkston · Clarkston, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Henry Ford Hospital · Detroit, MI
- Cancer Hematology Centers - Flint · Flint, MI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.