I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
NCT01042379
This study is recruiting at 32 US sites in 18 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learning more about which early indicators of response (tumor analysis prior to surgery via magnetic resonance imaging (MRI) images along with tissue and blood samples) are predictors of treatment success.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Breast Neoplasms
- Breast Cancer
- Breast Tumors
- Angiosarcoma
- TNBC - Triple-Negative Breast Cancer
- HER2-positive Breast Cancer
- HER2-negative Breast Cancer
- Hormone Receptor Positive Tumor
- Hormone Receptor Negative Tumor
- Early-stage Breast Cancer
- Locally Advanced Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- QuantumLeap Healthcare Collaborative
- Last updated on ClinicalTrials.gov
- May 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham · Birmingham, AL
California · 6
- University of California - Davis, Comprehensive Cancer Center · Davis, CA
- City of Hope · Duarte, CA
- University of California San Diego · La Jolla, CA
- University of Southern California · Los Angeles, CA
- HOAG Memorial Hospital Presbyterian · Newport Beach, CA
- University of California San Francisco (UCSF) · San Francisco, CA
Colorado · 1
- University of Colorado Cancer Center · Aurora, CO
Connecticut · 1
- Yale Cancer Center · New Haven, CT
District of Columbia · 1
- Georgetown University Medical Center · Washington D.C., DC
Florida · 2
- H. Lee Moffitt Cancer Center and Research Institute · Tampa, FL
- Moffitt Cancer Center · Tampa, FL
Georgia · 1
- Winship Cancer Institute of Emory University · Atlanta, GA
Illinois · 2
- University of Chicago · Chicago, IL
- Loyola University · Maywood, IL
Michigan · 1
- Herbert-Herman Cancer Center, Sparrow Hospital · Lansing, MI
Minnesota · 3
- University of Minnesota · Minneapolis, MN
- Mayo Clinic · Rochester, MN
- Metro Minnesota Community Oncology Research Consortium, Hennepin County Medical Center · Saint Louis Park, MN
New Jersey · 1
- Rutgers Cancer Institute of New Jersey · New Brunswick, NJ
New York · 5
- Roswell Park Cancer Institute · Buffalo, NY
- Columbia University Medical Center · New York, NY
- Laura and Isaac Perlmutter Cancer Center / NYU Langone Health · New York, NY
- University of Rochester Wilmot Cancer Institute · Rochester, NY
- Montefiore Medical Center · The Bronx, NY
North Carolina · 1
- Wake Forest Baptist Comprehensive Cancer Center · Winston-Salem, NC
Ohio · 2
- Cleveland Clinic · Cleveland, OH
- The Ohio State University, Stefanie Spielman Comprehensive Breast Center · Columbus, OH
Oregon · 1
- Oregon Health & Science Institute (OHSU) · Portland, OR
Pennsylvania · 1
- University of Pennsylvania (U Penn) · Philadelphia, PA
South Dakota · 1
- Sanford Clinical Research · Sioux Falls, SD
Utah · 1
- Huntsman Cancer Institute, University of Utah · Salt Lake City, UT
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.